News over a year ago as an archive on this page.
News in 2024
Merry Christmas
Landing Pages (Nov. 27th, 2024)
- https://www.emukk.com/WP/en/glycostation-reader-copy/
- https://www.emukk.com/WP/glycan-profiler-copy/
News (Reviews on Glycan Microarrays)
There is a discription about Glycan microarrays saying that “The typical concentrations for glycan microarray experiments use GBPs in the range of 5-200 μg/mL, and Glycan Binding Proteins (GBP) binding to typical printed glycan microarrays is detectable over a broad range of binding affinities, e.g., Kd’s of 10 μM to 10 nM; however, mM affinities are probably not observable.”
However, this problem can be easily overcome using GlycoStation. GlycoStation’s sensitivity is three orders of magnitude higher, and since it is a non-destructive measurement, it can detect even the weakest intermolecular interactions. (Sept. 24th, 2024)
News (Biosimilars and Lectin Microarray）
College of Pharmacy, University of Illinois and Faculty of Pharmaceutical Sciences, University of Iceland have emphasized the importance of the recent FDA results using lectin microarrays as a novel method for evaluating Biosimilars. The FDA has shown that the lectin microarray is useful in evaluating glycosylation in different manufacturing batches or comparing biosimilar and reference goods. This demonstrates its potential to speed up the development of biosimilars. The FDA´s conclusions significantly impact the understanding of characterization versus comparison. The key issue is maintaining the glycan profile, as found in clinical lots, as a measure of biosimilarity. (Setp. 15th, 2024)
News (hRTL paper)
A paper regarding hRTL lectin has been published on Marine Drugs. (Sept. 3rd, 2024)
News（Latest research on clam lectins)
Mx has supported An International Collaborative Research Seminar on clam Lectins held at Nagasaki International University (A special lecture sponsored by the Kyushu Yamaguchi Branch of The Pharmaceutical Society of Japan). (July 30th, 2024)
News (A novel method for rapid glycan profiling of therapeutic monoclonal antibodies)
Under the open access page of FDA’s homepage (/Home/Drugs/Science and Research/Drugs Regulatory Science in Action/), a tailored Lectin Microarray for therapeutic mAbs using GlycoStation was introduced as a novel method for assessing the glycosylation of antibody therapeutics. (June 22nd, 2024)
News (5th AGS)
5th AGS will be held in Wellignton, New Zealand on Aug. 27th-30th. Mx reprezentative will also be participating. (June 18th, 2024)
News (Glyco-core Symposium 2024)
Glyco-core Symposium 2024, sponsored by iGCORE, will be held on July 16th (Tue.) at Toyota Auditorium, Nagoya University. MX representative will also be participating. (June 12th, 2024)
News (Business forcast)
Since we are a LLC, it is not required to report financial results.
The fiscal year of Mx is from January 1st to December 31st. It is very happy to be able to report that we will be able to maintain a surplus as a half-year forecast. We have also been able to maintain debt-free management.
Although our ability is limited as a manufacturer and distributor of glycan and lectin-related products, we will continue to work hard to provide the better services to customers. We appreciate your continued support. (May 31, 2024)
News（New Product Development）
We will develop a compact, inexpensive, and highly sensitive glycan array that can easily profile the glycan binding specificity of lectins covering a wide range of glycan epitopes. Several types of glycan arrays already exist on the market, but most arrays require a sample volume of several tens of μg/mL. In the case of trace amounts of markers or extracts from rare natural products, the sample preparation is difficult to meet the requirements.
Our target glycan array can easily profile glycan binding properties even at concentrations at the ng/mL level. This glycan array is also highly compatible with the world’s most sensitive evanescent-field fluorescence excitation scanner (GlycoStation), making it possible to obtain highly reliable data, no matter how weak the bond is.
stay tuned! (May 9, 2024)
News (the 4th anniversary event: Half price sale)
Mx will be holding a half price sale on GSR2300 as the 4th anniversary event. First come first served, limited to only 1 unit. Please contact us for special pricing. (May 3rd, 2024)
News (Carbohydrates related International Conferences)
Carbohydrates related International Conferences which will be held in overseas in 2024-2025 was summarized. (May 7th, 2024)
News（Updated Information about GlycoStation Related Products）
The most recent Information about GlycoStation related products (GSR22300, GSL-2200, and IgG1-mAb-LecChip) was uploaded for your information. Since some Video were embeded in this document, PowerPoint was used instead of pdf. (Feb. 1st, 2024)
News（A tailored Lectin Microarray for therapeutic mAbs）
FDA has published a paper on lectin microarrays for simple and rapid therapeutic mAbs. This result was also a joint study between FDA and GlycoTechnica. In this paper, Glycan Profiler GSR2300 and 14-well lectin microarrays using 9 kinds of carefully selected lectins were used. (Jan. 26th, 2024)
News（New Year’s Greetings）
A Happy New Year.
Thank you very much for your help and support for our company during the past year. We look forward to continuing work with you in 2024.
News in 2023
News（FDA announced a new LecChip using 9 kinds of lectins for evaluation of IgG1 mAbs glycan epitopes: Rapid Glycan Profiling)
FDA has recommended using a new IgG1-mAb-LecChip to pharmaceutical companies when developing IgG1mAbs to assess batch-to-batch or biosimilar-to-innovator glycan epitopes. GlycoStation Reader 2300 (GSR2300) is used in this work. Take a look at Mx blog site in more detail. (Dec. 8th, 2023)
News（New scanning mode covering a wider scan area: GSR2300）
By default, GSR2300 uses a dedicated scan mode (1×7 mode) that supports the LecChip format. We have now added a wide area scan mode (4×8 mode) so that you can scan a wider area. The mode change can be done just by rewriting a GSR definition file. This mode allows an area of 24mm x 68mm to be scanned. When scanning the LecChip under this mode, specify a 2×7 area as the scan area as shown in the figure below.
News（Trial Sales of OBS）
We will start trial sales of optic biome sensor (OBS) from March 2024. (Oct. 22nd, 2023)
News（AGRI WEEK TOKYO2023）
We have a booth in the coming AGRI WEEK TOKYO2023. To visit this Show, please use this e-Invitation, otherwise you have to pay 5,000 JPY to enter this show.
Our booth location is 7-51. We are looking forward to meet you there. (Sept. 9th, 2023)
News（343 Poster Presentations@Glyco26)
There seems to be 343 Poster presentations in the upcoming Glyco26. There are three posters in which my name (Masao Yamada, emukk LLC) is included. If you have a time, please drop by the following posters. (Aug. 22nd, 2023)
A030、Yuki Fujii, Nagasaki International University, Japan
Discovery of the First R-type Lectin from Mytilidae (sea mussels) and its Cellular Function
A031、Ryuhei Hayashi, Yokohama City University, Japan
Purification of Tumor-associating Glycan-binding Lectins from the Marine Sponges
C050、Patcharaporn Boottanun, National Institute of Advanced Industrial Science and Technology, Japan
Improved Tissue Glycome Mapping Technique Revealed Cardiac Fibrosis-related Glycosylation Alterations in Rats with Hypertensive Heart Failure
News（AGRI WEEK Tokyo）
We will have a booth at the Japan’s Largest Show for Agricultural Technology, AGRI WEEK Tokyo. It became possible to search Exhibitors in this show. (Aug. 1st, 2023)
News (Stability of OBS)
The stability of OBS is very high with a very small noise ±0.1mV, having a measurement dynamic range of 5 orders of magnitude. (Jul 27th, 2023)
News (Measurement of Pseudomonas spp.)
It bacame possible to measure Pseudomonas spp. relatively widely in the low concentration range (from 200,000 cells/CC to 200 cells/CC) by Optic Biome Sensor (OBS) with adopting a new probe. The detailed explanation is written in the OBS site. (Jul. 24th, 2023)
News (Appearance image of OBS product version)
Here is an appearance image of Optic Biome Sensor (OBS) product version. We will continue to accumulate basic data. Stay tuned. (Jul. 7th, 2023)
News (Latest paper about GSR2300)
A latest paper discribing the high sensitivity of GSR2300 has been just published. It was demonstrated that cell glycomic profiling could be performed with only three cells using HEK293T cell lysates, which has the potential for the glycomic profiling of cell subpopulations. In this paper, GSR2300 was called as mGSR1200-CMOS scanner. (Jul. 4th, 2023)
News（Release of Lectin Microarray）
We are sorry to have kept you waiting for a long time.
Regarding the lectin microarray, our partner company has officially announced the start of manufacturing and sales of Lectin Microarrays. The partner company is Precision System Science Co., Ltd. (PSS).
The name of the released lectin microarray is LecChip®45-uni, and it uses the same format as LecChip Ver1.0 which was manufactured and sold by GlycoTechnica. However, No.44 GSL-I-A4 is not installed as shown below.
This lectin microarray can be scanned by GlycoStation® Reader and analyzed with GlycoStation® ToolsPro, the comparative glycan profiling analysis software, without problems as with LecChip Ver1.0. A compatible Lectin Microarray with LecChip Ver2.0, which was also manufactured by GlycoTechnica, will be released shortly. (Jul. 3rd, 2023)
LecChip® is a registered trademark of PSS, and GlycoStation® is a registered trademark of Mx.
News（OBS for a Gram-negative bacteria）
Regarding the sensitivity of the optic biome sensor (OBS) and the measurement range of the number of target bacteria, we have already completed data acquisition for Bacillus, a Gram-positive bacterium. We have also obtained a calibration curve for Pseudomonas, a Gram-negative bacterium. We are going to upload the data in a couple of days. (May. 26th, 2023)
News（Poster Presentation）
At Glyco26, which will be held from Aug. 27th to Sept. 1st, 2023, we are going to present two posters. One is a result of joint research with Dr. Atsushi Kuno et al., AIST, and it will be shown that it is possible to take glycan profiles from just a few cells using GSR2300. The other is a result of joint research with Prof. Yasuhiro Ozeki et al., Yokohama City University, and the results of analyzing the glycan binding specificity of lectins extracted from marine animals using glycan microarrays will be presented. (May. 10th, 2023)
News（JCGG2023）
Although it is small, we have decided to support the 20th JCGG2023 symposium. (Apr. 15th, 2023)
News（OBS for a Gram-positive bacteria）
Information on the sensitivity of the optic biome sensor (OBS) and the measurement range of the target bacteria (in terms of bacterial concentration = number/mL) has been discolsed on the following page, Basic performance of OBS. (Apr. 7th, 2023)
News (Optic Biome Sensor: OBS)
The prototype of Optic Biome Sensor (OBS) unit 2 has been completed. In this unit, the optical fiber can be replaceable, and the housing is made of black almite with improved robustness. The purpose of this unit is a functional test before commercialization, improving the level of completeness, and minimizing differences between models. The size of OBS is the size of a smartphone. It will also be used for data accumulation for application development. (Feb. 15th, 2023)
News (Business alliance agreement)
Our company and Precision System Science Co., Ltd. signed a business alliance agreement on February 10, 2023.
News (Conference）
The new coronavirus has passed the peak, and restrictions on overseas travel have become normal these days. Three years have passed since my last overseas trip. This year, we plan to participate in Glyco26, which will be held in Taiwan from Aug. 27th to Sept. 1st, 2023. (January 30, 2023)
News (AGRI WEEK TOKYO 2023)
Emukk will display its strategic development products in the coming AGRI WEEK TOKYO 2023 (from Oct. 11th to 13th, 2023) (Jan. 23rd, 2023).
News (Lectin microarray)
The supply of lectin microarrays is expected to start around April 2023. We apologize for any inconvenience this may cause, and ask for your patience for the time being (Jan. 6th, 2023).
News (Company name）
The registered company name is ”合同会社エムック” in Japanese. “Mx” will be used as a company logo (Jan. 6th, 2023).
News (emukk LLC）
A Happy New Year.
Mx（emukk）will be registered as “emukk LLC” to Tsu Legal Affairs Bureau, shortly (Jan. 1st, 2023).
News in 2022
News (Remarks）
The glycan profiling analysis software GlycoStation® ToolsPro Ver1.5 and Ver2.0 does not work on Windows 11. To use ToolsPro on Windows 11, you need to purchase Ver3.0 (December 8th, 2022).
News (Price Revision）
Due to the serious impact of rising prices for semiconductor parts, we will revise the list prices of the glycan profilers. The list price of GlycoStation® Reader 2300 (GSR2300) is kept as used to be, and that of GlycoSuperLite 2200 (GSL2200) is 10% up. The list prices are subject to change by the currency exchange fluctuation (November 24th, 2022).
News (Glycan Profiler)
A detailed explanation about performance of GlycoStation® Reader 2300（SR2300）was uploaded (November 20th, 2022). Performance of GSR2300
Five key persons talk about typical applications of Lectin microarrays. Essence of comparative glycan profiling analysis using Lectin microarrays
News (Standardization)
Standard formats of Lectin microarray were uploaded (November 19th, 2022). Standard formats of Lectin microarrays (Standarization of Glycan analysis technology)
News (Website protection from Bot)
reCAPTCHA was installed in this Homepage (November 11th, 2022). What is Google’s reCAPTCHA?
News (Blogs)
As for SARS-CoV-2, mRNA vaccines have worked so well, and no therapeutic drugs, except antibody cocktail therapy, have shown sufficient effects against it. The pandemic seems to be coming to an end soon, and I would like to end the topic of SARS-CoV-2 on the Mx blog (October 28th, 2022).
News (Standardization)
The standard protocol for Lectin Microarrays was uploaded. Standard protocol for lectin Microarrays
News (Lectin microarray)
There are two types of lectin microarrays, Ver1.0 and Ver2.0, which are manufactured and supplied by a partner company. Please contact us when ordering. The information about lectins and their glycan binding specificity are written in Products & Services page. Introduction of Products & Services (Glycan profiler, Analysis software, Lectin microarray, Culture media etc.)
News (R&D)
Prof. Sakar M. A. Kawsar (University of Chittagong, and Visiting Prof. Yokohamacity University (YCU)), Dr. Masao Yamada (Mx representative and Visiting Prof. YCU), and Prof. Yasuhiro Ozeki (YCU), etc. have reported about new inhibitors for SARS-CoV-2 protease enzyme. Inhibitors for SARS-CoV-2 protease enzyme
News (R&D)
At the 45th Annual Meeting of the Molecular Biology Society of Japan, November 30th to December 2nd, 2022, at Makuhari Messe, a presentation titled as “Evaluation of an improved evanescent fluorescence scanner suitable for high-resolution glycome mapping of formalin-fixed paraffin-embedded tissue sections ” will be presented as a joint activity with researchers from Molecular and Cellular Glycoproteomics Research Group, Cellular and Molecular Biotechnology Research Institute, AIST. You can see glycan profiling from a quite small sample using the high-performance glycan profiler GSR2300. The 45th Annual Meeting of the Molecular Biology Society of Japan
News (New Business Development)
Team AgroHolobiont (Mx is the main member of this team) was selected as one of the finalists in AGRI TECH Grand Prix 2022. Mx is engaged in developing a Microbiome Sensor (MBS).
Strategy of AgroHolobiont to realize Regenerative and Sustainable Agriculture
News (Glycan Profilers)
Mx will start Manufacturing and Sales of Glycan Profilers (GlycoStation® Reader 2300, GlycoSuperLite 2200) after 2022, Aug. 12th. It will be also possible to handle Repair and Maintenance of old products sold from Moritex, GP Biosciences, and GlycoTechnica, of course it will depend on equipment conditions and repair parts availability. The trademark “GlycoStation” has also been transferred from GlycoTechnica to Mx.
News (New Product)
Let me introduce you an ultra-low-cost, ultra-high-speed, high-sensitivity glycan profiler (GSL2200). Please refer to the following pdf for the specifications of the device, including the comparison with the current Highend glycan profiler. GlycoSuperLite was released